Who are the good guys?

Are there good and bad bacteria?

If you are the inventor of an anti-microbial technology one of the more frequently asked questions you  get goes something like this, “I really understand the need to kill the bad and dangerous  germs… but how do you make sure you don’t kill the good bacteria as well?” The answer I give often causes the person asking momentary alarm, because I say quite simply that I don’t distinguish bacteria as good or bad because Byotrol is specifically designed to kill them all! 

Nearly always eyes widen as the questioner quietly assesses me and quickly places me in the heartless and brutish category that is nowadays normally only reserved for Imperial Tiger hunters in the 1920’s.

Most people normally give me the chance to redeem myself, allowing me to explain why this is not a bad, dangerous or terrible thing. I firmly believe that when thinking of  bacteria and microbes they are neither good or bad, the  usual problem with them is that they get in the wrong place (for humans!) and because they are so tiny they can get  virtually everywhere.

Take for instance the bacteria that live in your gut, an amazing bunch of microbes that work 24/7 helping to digest food and keep you nourished and ultimately alive! Surely these are the good guys!  However just imagine your horror and disgust if you discovered that there was a dose of faecal bacteria on a sandwich you had just been given! Good bacteria just in the wrong place….

Put another way, just about everyone agrees that honey bees are a fantastically “good” insect, and that nature in general and farmers in particular would be in serious trouble without them. Those warm appreciative feelings tend to quickly dissipate if you like me, put your bare foot into a shoe that contains one….

So are there Bacterial good guys?  The answer is a resounding yes (Just think Beer (Yeasts) and Cheese (fungi) if you are not sure!) And as for the other end of the scale even the most dreadful of infectious disease causing pathogens are they really bad? I would say certainly they are dangerous, but bad… I am not so sure.

So I hope we can stop thinking of good and bad bacteria, let’s just think of them as where they should be and where they should not be. If they are where they should be … great!  If they are where they should not be, then the best way is to get rid of them all, simply and safely and whilst doing that make sure it is really hard for them to quickly come back…. seem like a good Idea? I certainly think so.

 

Digging Holes and Building Cathedrals

After the Great Fire of London a writer of the day was walking over London Bridge towards a scene of devastation and saw two individuals a few feet apart busy with spades. He approached the first and asked what he was doing. “I’m digging a bloody hole!” said the worker with some irritation. Still curious the gentleman asked the second toiling man what he was doing. After a small pause the second chap said “… I am building a cathedral!”

Sometimes building a business makes me feel a bit like I am the first worker. With my back bent over some of the problems and challenges of the day it feels like I am just digging a hole. But on other days everything comes together. I feel inspired, part of the great plan is coming to fruition and it really does feel like we are building something very special.

Byotrol quite often has a monumental feel about it, just the other day we had a “Cathedral” moment. We heard that in a simple study (in a quite disadvantaged and under resourced medical clinic) in the Sudan the use of Byotrol on the maternity wards and in the air conditioners has helped to significantly reduce patient mortality rates. To say this made the whole team feel good is an understatement (as big as saying Jenson Button was satisfied when he was crowned Grand Prix Champion of the world!)

To be told that something you have worked on and been passionate about has contributed to saving a single life young or old is a fantastic thing. Just knowing that somewhere, someone you may very well never meet will live their life and get the chance to see all the great buildings of the world, because of a technology we have developed to combat the germs that cause disease and infection, makes all the days of digging holes fantastically worthwhile!

Scaling The Microbes

“Big fleas have little fleas
Upon their backs to bite ’em
And little fleas have lesser fleas
And so ad infinitum”
Dean Swift

A few weeks ago our pet hamster called rather confusingly “the mole” died and was sent to his maker in a touching ceremony in the flower bed. I have always liked small animal pets and something that always amazed me with them is how can something so small can have a fully functional, heart, liver, lungs … the lot! Life really does come in all shapes and sizes and we tend to forget that in the great scheme of things we are really REALLY big. Not really a case of the hamster being small but us being, by the standards of the planet very big indeed.

The largest creature that has ever lived on the earth is the blue whale and  the biggest of them would be 100 feet long (or tall if you like) this is  less than 17 times bigger than a normal adult human , and about the same ratio as me to my late lamented hamster.

Still, even the hamster really wasn’t that small at all when compared with most of the life on earth, microbes, they are small,… really small, but how small?

Sometimes it is hard to think in the measurements scientists use. Most of us know roughly how big a meter or centimetre is, but what about a nanometre?

I prefer to think of things in relation to others (The old football pitch or tennis court measure still helps me get a real feel for certain distances and size). So when trying to scale a microbe I like to think of a dog like a Labrador and call it 1 dog unit in size, ten times smaller than the dog and we get to a mouse, ten times smaller again we get to a fly which is one hundredth of the size of a dog!

Another ten times we get to a tick, ten times smaller again, just on the edge of our vision we get to a dust mite. Ten times again and we get to a red blood cell (which is one hundred thousandth of a dog unit). At a millionth of the size of our truly enormous dog we finally get to a bacteria such as E.coli.

Ten times smaller we get to viruses and I think there we get to the very border of the building blocks of life, because ten times smaller than that (or one hundred millionths of a dog) is a DNA molecule.

After this the Physics boys come in, and we can keep getting smaller and smaller!

Some might say I am obsessed with size… well after all I am a bloke! But seriously the thing that really comes home to me is that microbes are very numerous and can, in some cases be harmful to the bigger stuff, like us (and “the Mole”).  This got me thinking, in order to keep the bigger stuff safe and healthy we needed to rethink how we deal with the miniscule stuff. A few years ago some colleagues and I developed an anti-microbial technology which focuses its killing power only on microbes (unlike bleach that indiscriminatingly attacks everything). You could say we picked on the microbes because of their size!

Autumn Cleaning Keeps The Bugs At Bay

Winter is just around the corner and it seems the whole of nature is responding. Birds fly overhead determined to get to warmer lands, the trees shed their leaves and we all wrap up and grumble about the weather.

It is easy to forget that Microbes are part of nature too… a huge part of it, and winter has a big effect on them also. They do not fly south for the winter, nor do they retreat into the soil until spring. For many bugs, winter is a time of growth and opportunity, and for us that means it is a time for care and attention.

Now that the sun is weaker, those summer UltraViolet rays do not do as much damage to viruses out in the open, allowing them to survive in infectious state for longer than in the summer. Damp, starts to become worse in and out of our homes and provides the perfect place for bacteria to survive, with cool moist conditions allowing bugs that normally quickly dry out and die, a longer period to stay alive and a longer opportunity to find a nice warm home in our houses or in our bodies!

We often notice the mushrooms and toadstools that appear in our gardens and woods, but just like these fungi the ones closer to our homes (and living in) the moulds and mildews are also producing spores and in doing so causing problems in breathing for many of us.

Knowing that winter is a time when bugs can survive longer to transfer about and even infect us with colds or even Swine flu, tells us something. That something is that we too should change the way we act a little to respond to the season. Using tissues when we sneeze is wise at all times, but especially in winter is a really practical way to stop germs spreading. Washing your hands and keeping them hygienic, really matters! Just imagine putting your mouth where your hands touch on say a tube journey or a bus ride…fancy a lick of that grab handle…er no! Your hands go there all the time! So in winter especially, taking care in keeping them clean will make a difference.

It might seem that the outlook is pure gloom, but the good thing is that numerous micro-organisms are not too cunning, so they will not sneak about or hide when they see you coming to clean! My idea is we all abandon the idea of Spring cleaning and have Autumn and Winter clean instead! That way we can spend the gloomy grey days keeping our lives cleaner and healthier, and spend the Spring days enjoying nature as the leaves return and the birds fly back!

Byotrol Press Release – Alcohol hand-gel “no defence” against Swine Flu

Prisoners get drunk on alcohol hand-gel. Many Muslims can’t even use it. Alcohol hand-gel should be “a thing of the past.”

Healthcare experts gathered in Harrogate last week for a conference hosted by the Infection Prevention Society, the leading medical conference in the field of infection control.

Groundbreaking research was presented to the conference that suggests alcohol-based hand cleaners are no longer the most effective first line of defence in infection prevention.

Alcohol-based hand gels have several significant drawbacks, which have led manufacturers to invest heavily in finding a safer, easier and more effective hand sanitiser.

One such manufacturer is Manchester-based Byotrol, who have set themselves the task of leading a “hygiene revolution.”

Byotrol hand-foam, based on new “micro-polymer’’ technology, has been proven to demonstrate superior protection against the swine flu virus, and is unique as it delivers long lasting anti microbial protection compared to alcohol based products which stop working as soon as they dry.

Stephen Falder, the company’s deputy chairman, developed their water-based hand-foam that actually out-performs leading alcohol hand-washes in killing and preventing the germs which cause swine flu and hospital superbugs. 

Mr Falder says “Alcohol hand-washes have run their course. They are no longer the most effective products. Nurses complain of dry and damaged skin caused by alcohol hand gel, prisoners are getting drunk on the stuff, many Muslims can’t touch alcohol and, to top it all, it isn’t even very effective when you consider that it stops working as soon as it evaporates – which is almost immediately.”

Byotrol’s micro-polymer technology forms an invisible protective layer on any surface, be it human hands or a hospital floor. Independent laboratory tests have demonstrated Byotrol’s effectiveness in killing the swine flu virus and have also shown that Byotrol kills viruses for at least 17 hours after application to hard surfaces – unlike conventional disinfectants which stop working when dry.

An 11-month study at the Manchester Royal Infirmary, which was widely reported in late June, showed that Byotrol was 30 per cent more effective than conventional cleaners in reducing the superbugs MRSA and C-Difficile.

Similar tests at Monroe Hospital in Indiana, America, have resulted in there being no cases of MRSA or C-Difficile for over 3 years since Byotrol became their standard cleaning product.

Lord Warner, the former government Health Minister, who is an adviser to the company, said: “The scientific evidence proves that Byotrol products mark a step-change in the fight against the swine flu pandemic. The long-lasting nature of the product, combined with its safety, means that Byotrol hygiene products have the potential to revolutionise the way we deal with swine flu and superbugs.”

 

 

Smart Hand Hygiene Will Help Stop The Spread Of Swine Flu

 

 

Apparently when Winston Churchill planned his own funeral he gave it the code name “Operation Hope Not!” in a way this is how I feel about the current concerns over a possible significant outbreak of Pandemic Flu.

 

From the end of last week there were growing indications that the possibility of a major pandemic flu outbreak could be about to start. The really big difficulty here is the balance of vigilance and swift action, and the fear of “Crying wolf!”

 

 

I believe that really effective and swift action can act to prevent a pandemic in the same way that rapid extinguishing of small blaze can prevent a forest fire. The problem with that is that whilst everyone agrees prevention is better than cure, It is not easy to be certain when a real catastrophe has been avoided, and we can always (After no terrible losses) wonder if this was a disaster averted or just a fizzle.

 

The stakes are high (enormous) with estimates of a real pandemic causing tens of millions of deaths worldwide as well as an estimate of cost of $3trillion! So for us every alarm needs to be taken seriously.

 

Byotrols safe effective long lasting action make it pretty ideal for the preventive vigilance required during a pandemic alert. Using it on hands after sneezing and coughing and before eating make perfect sense at the best of times and particularly now are a really good habit to acquire.

 

All of my team are slightly nervy about seeming to profit from misfortune but we have a real sense at the moment that we can make a difference, because even if (and I hope it is) the current alarm turns out to be an epidemic that never fully took hold. The behaviour of taking hand hygiene seriously, without developing an obsessive compulsive disorder is a good life habit whether it is protecting your self against Swine Flu or as part of your daily hand hygiene routine.  By taking a few simple proactive steps we can all safeguard our own health and reduce the spread of diseases.

Novel Use of Antimicrobial Hand Sanitizer in Treatment of Nosocomial Acinetobacter Infection

By Meghan Donahue, MS; Luke R. Watson, MD; Alfonso Torress-Cook, DrPH; Paul A. Watson, MD
ORTHOPEDICS 2009; 32:58

January 2009

Abstract

Colonization of wounds with multidrug-resistant organisms is a difficult orthopedic problem. Acinetobacter infections are especially difficult because they are resistant to all currently available antibiotics. We present the use of a novel skin sanitizer, Stay Byotrol Clean (Byotrol Inc, Spartanburg, South Carolina), to treat a multidrug-resistant wound infection.

A 31-year-old T10 paraplegic man presented with chronic bilateral stage IV decubitus trochanteric ulcers. Cultures grew methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus. The ulcers were initially treated with irrigation and debridement and vancomycin, levaquin, and cefepime. After 4 months of aggressive treatment, the cultures continued to be positive for Escherichia coli and Acinetobacter baumannii. The patient was started on amikacin and tigecycline. Despite 1 additional month of aggressive wound care, debridements, and intravenous antibiotics, the cultures continued to grow A baumannii and Pseudomonas aerug. The A baumannii was resistant to all available antibiotics tested. The ulcers were then treated with daily application of Stay Byotrol Clean hand and skin sanitizer. Four days later, cultures were negative for any bacterial growth, with no A baumannii. After 1 week, the ulcers showed new granulation tissue with no visible necrotic tissue. After 3 months of treatment, the ulcers had healed.

Stay Byotrol Clean is nonirritating and contains no iodine or alcohol. It is currently being used for decolonization of patients on admission to the hospital, however, there is great potential for its use in wound treatment, preoperative surgical sterilization, and orthopedic devices.

Colonization of wounds with multidrug-resistant organisms is a difficult orthopedic problem. Acinetobacter infections are especially difficult because they are resistant to all currently available antibiotics. This article presents a case of a 31-year-old paraplegic man with bilateral stage IV decubitus hip ulcers colonized with antibiotic-resistant Acinetobacter baumannii. After 4 months of treatment, including antibiotics, multiple debridements, aggressive wound care, and nutrition, the Acinetobacter infection persisted. The wound was then treated with Stay Byotrol Clean (Byotrol Inc, Spartanburg, South Carolina), a new persistent antimicrobial hand- and skin-sanitizing foam known to kill Acinetobacter, and the infection resolved.

 

Case Report

A 31-year-old T10 paraplegic man presented with chronic bilateral stage IV decubitus trochanteric ulcers with exposed necrotic greater trochanteric bone bilaterally (Figure 1). The patient’s right hip wound measured 11×12 cm and left hip wound measured 10×14 cm. Cultures grew methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus. Initial treatment included irrigation and debridement; vancomycin, levaquin and cefepime; aggressive nutrition; and local wound care with wound wax and silver nitrate paste. After 4 months of wound care and gaining 45 lbs, the patient was discharged home with continued home wound care.

Three days later, the patient returned with fevers and foul-smelling discharge from the bilateral decubitus ulcers. Levaquin and aggressive wound care with wet-to-dry dressings were started. The patient underwent a repeat irrigation and debridement of the wounds. Wounds cultures were positive for Escherichia coli and Acinetobacter baumannii. Blood cultures were negative. The patient was put on amikacin and tigecycline. Despite 1 additional month of aggressive wound care, the bilateral hip cultures continued to grow Acinetobacter baumannii and Pseudomonas aerug. The Acinetobacter baumannii was resistant to all available antibiotics tested.

Following the second culture positive for Acinetobacter baumannii, the decubitus ulcers were treated with daily application of Stay Byotrol Clean skin-sanitizing foam and received daily dressing changes and wound care. Four days later, cultures were negative for all bacterial growth with no Acinetobacter baumannii. Eight days later, the ulcers showed new granulation tissue with no visible necrotic tissue (Figure 2). The right hip ulcer measured 3.5×4 cm and the left hip ulcer measured 10×10 cm. The wounds remained negative for growth and healed after 3 months of treatment.

Discussion

Multidrug-resistant organisms are a major problem for surgeons.¹ Acinetobacter, a pleomorphic aerobic Gram-negative bacillus, is commonly found in the hospital environment.² Acinetobacter colonization is found among the general public, but because of low virulence, infection is rare and usually only found in very ill patients.³ There are at least 32 species of Acinetobacter, but Acinetobacter baumannii is responsible for the majority of infections. Studies of Acinetobacter baumannii infections show that up to 90% are hospital acquired.⁴ This organism rapidly acquires antimicrobial-resistant genes and survives antimicrobial environments.⁵ Since its discovery, Acinetobacter baumannii has developed resistance to almost all commercially available antibiotic drugs, including carbanapem, cephalosporins, aztreonam, aminoglycosides, and ciprofloxacin.⁶

Risk factors for resistant Acinetobacter baumannii infection include previous antibiotic use, hospitalization, nursing home residency, Foley catheterization, intensive care unit stay, and invasive procedures.⁵ Due to limited treatment options for resistant Acinetobacter baumannii, patients infected with this pathogen have increased severity of illness and mortality rates when compared to nonresistant Acinetobacter baumannii.⁷ As the number of multidrug-resistant organisms increases, so does the need for antimicrobial products to treat patients infected with these pathogens.

Stay Byotrol Clean (benzalkonium chloride 0.1%) skin sanitizer is a commercially available product widely used in the United Kingdom and only recently available in the United States. Laboratory analysis has shown that Stay Byotrol Clean has antimicrobial properties against multidrug-resistant organisms, including drug-resistant Acinetobacter spp, methicillin-resistant Staphylococcus aureus, Clostridium difficile, and vancomycin-resistant Enterococcus. In addition to the biocide benzalkonium chloride, the Byotrol technology (a polymer layer) is thought to have a physical effect that rapidly disrupts the microbe’s ability to reproduce and maintain colonies, preventing biofilm formation. Because it is alcohol- and iodine-free, it is less irritating than many antibacterial and surgical scrubs used in health-care facilities. Stay Byotrol Clean also appears to prevent recolonization. Stay Byotrol Clean is currently being used for decolonization of patients upon admission to the hospital, but there is great potential for Stay Byotrol Clean to be used in wound treatment, preoperative surgical sterilization, and orthopedic devices.

Patient safety is imperative for all medical treatment options, and our patient was counseled carefully prior to consenting to treatment. Stay Byotrol Clean is not FDA compliant as a wound sanitizer, only as a skin sanitizer. The active ingredient in Stay Byotrol Clean is benzalkonium chloride, which is used in mouthwash and as a preservative in eye drops and nasal sprays.

Marple et al⁸ reviewed 18 studies on the safety of benzalkonium chloride in nasal solutions and concluded that benzalkonium chloride appears “safe and well tolerated for both long- and short-term clinical use.” Benzalkonium chloride has also been tested in vitro as a wound irrigant. Gainer et al⁹ compared benzalkonium chloride to normal saline irrigation in beef muscle strips inoculated with bacteria and found that benzalkonium chloride was an effective wound disinfection agent. Tarbox et al¹⁰ evaluated the efficacy and toxicity of benzalkonium chloride as an irrigant in rats and found that benzalkonium chloride was more effective than normal saline at eradicating Staphylococcus aureus with no toxicity noted on histological examination. As well, Conroy et al¹¹ studied in vitro rat wound irrigation with benzalkonium chloride vs normal saline, castile soap, and antibiotics. Benzalkonium chloride was the only irrigation that significantly lowered the rate of Staphylococcus aureus.

Although benzalkonium chloride appears to have a good safety profile for use on mucus membranes, is an effective in vitro irrigant, and caused no adverse reactions clinically in our patient, further study is needed to verify Stay Byotrol Clean’s safety as a wound decolonization agent.

Conclusion

Nosocomial Acinetobacter wound infections are a major problem for surgeons due to their antibiotic-resistant properties. This case report documents the use of a new product that may be used to treat such infections. Because Stay Byotrol Clean foam is nonirritating and contains no iodine or alcohol, it is an ideal candidate for wound treatment. The foam not only kills multidrug-resistant bacteria on contact, but also creates a barrier that prevents recolonization and the formation of bacterial biofilm. Stay Byotrol Clean is currently being used for decolonization of patients upon admission to the hospital, but there is great potential for Stay Byotrol Clean to be used in wound treatment, preoperative surgical sterilization, and orthopedic devices.

References

1. Cisneros JM, Rodríguez-Baño J. Nosocomial bacteremia due to Acinetobacter baumannii: epidemiology, clinical features and treatment. Clin Microbiol Infect. 2002; 8(11): 687-693.
2. Fournier PE, Richet H. The epidemiology and control of Acinetobacter baumannii in health care facilities. Clin Infect Dis. 2006; 42(5):692-699.
3. Gerner-Smidt P, Tjernberg I, Ursing J. Reliability of phenotypic tests for identification of Acinetobacter species. J Clin Microbiol. 1991; 29(2):277-282.
4. Rodríguez-Baño J, Cisneros JM, Fernández-Cuenca F, et al. Clinical features and epidemiology of Acinetobacter baumannii colonization and infection in Spanish hospitals. Infect Control and Hosp Epidemiol. 2004; 25(10):819-824.
5. Mahgoub S, Ahmed J, Glatt AE. Underlying characteristics of patients harboring highly resistant Acinetobacter baumannii. Am J Infect Control. 2002; 30(7):386-390.
6. Van Looveren M, Goossens H, ARPAC Steering Group. Antimicrobial resistance of Acinetobacter spp. in Europe. Clin Microbiol Infect. 2004; 10(8):684-704.
7. Sunenshine RH, Wright MO, Maragakis LL, et al. Multidrug-resistant Acinetobacter infection mortality rate and length of hospitalization. Emerg Infect Dis. 2007; 13(1):97-103.
8. Marple B, Roland P, Benninger M. Safety review of benzalkonium chloride used as a preservative in intranasal solutions: an overview of conflicting data and opinions. Otolaryngol Head Neck Surg. 2004; 130(1):131-141.
9. Gainor BJ, Hockman DE, Anglen JO, Christensen G, Simpson WA. Benzalkonium chloride: a potential disinfecting irrigation solution. J Orthop Trauma. 1997; 11(2):121-125.
10. Tarbox BB, Conroy BP, Malicky ES, et al. Benzalkonium chloride. A potential disinfecting irrigation solution for orthopaedic wounds. Clin Orthop Relat Res. 1998; (346):255-261.
11. Conroy BP, Anglen JO, Simpson WA, et al. Comparison of castile soap, benzalkonium chloride, and bacitracin as irrigation solutions for complex contaminated orthopaedic wounds. J Orthop Trauma. 1999; 13(5):332-337.

Authors

Ms Donahue is from Creighton University Medical School, and Dr Watson (Paul) is from Lakeside Orthopaedics, Omaha, Nebraska; and Drs Watson (Luke) and Torres-Cook are from Pacific Hospital Long Beach, Long Beach, California.

Ms Donahue has no relevant financial relationships to disclose, and Drs Watson (Luke), Torress-Cook, and Watson (Paul) own Bioblockade LLC, a company that distributes Byotrol products.

Correspondence should be addressed to: Paul A. Watson, MD, Lakeside Orthopaedics, 16909 Lakeside Hills Ct, #208, Omaha, NE 68122.

The Hygiene Revolution

It’s not everyday you discover a technology that could change the life of every person on the planet. But that’s exactly what happened to the Byotrol team, inventors of the world’s most revolutionary hygiene technology.

Byotrol delivers what no current technology can do; broad spectrum, long lasting, anti microbial control in a much safer and more caring way than was ever believed possible. We describe it as the silicon chip moment for hygiene.

Discovered in 1999 the technology has undergone nearly a decade of extensive testing by the worlds major regulators. It is now approved safe for use in the high need hygiene environments of healthcare, food production, animal welfare and the home. Early results in these environments have been astounding.

At Monroe hospital the use of Byotrol as part of the hospital’s disease control program has meant no hospital-acquired infection from the so-called super bugs (MRSA, C. difficile and VRE) in 2 years.

In food factories Byotrol has enabled already clean factories, to set new standards of hygiene frequently eliminating microbes completely from the food chain.

In over 250 dairy farm tests with over 170,000 dairy cows, Byotrol has made across the board improvements. Their farmers are reporting cleaner milk, better condition cows, and in many cases more milk!

The goal of the business is to become a world leader in the provision of anti-microbial technology and in doing so fulfil our vision of creating easier, cleaner and safer lives for everyone.

To achieve this goal the business is seeking to work in partnership with a number of global businesses and healthcare organisations that share our passion and belief in the technology and the benefit it can bring to the world.

What is Byotrol?

Byotrol is a next generation hygiene technology, described by experts in the field as having the characteristics of the ideal biocide. Byotrol offers a combination of unique and highly attractive characteristics never available before in one anti microbial technology:

• Broad-based efficacy across all microbial classes, bacteria, viruses, fungi,  moulds micobacteria and algae)
• Fast acting effect; log 7 reduction in 30 seconds (99.99999%)
• Residual, durable, long lasting efficacy on all surfaces
• Extremely low risk of microbial resistance  
• Low toxicity to animals & plants
• Strong environmental credentials
• Relatively low cost

These characteristics mean that Byotrol offers a combination of power and gentleness that is unique.  

Byotrol has been registered and approved by the world’s major regulators (EPA and FDA in the United States.  The products are covered and included in the European BPD & REACH) with the first products using Byotrol now on sale in Europe, Asia, the America’s and Africa.

Welcome To The Byotrol Blog

Hello and welcome to the Byotrol blog, here you can learn all about Byotrol or just keep up to date with our latest new. For more information please visit our website www.byotrol.com 

 

Listen to the inventor, Stephen Falder, tell the story of Byotrol